Cradle

Cradle is an AI-powered software that allows users to design improved variants of protein sequences quickly and accurately. With Cradle, users can import assay data from ongoing projects or start fresh with a single starting sequence. The software generates sequences with predicted performance scores, reducing surprises in the lab. It learns from each experimental round, providing better variants over time and significantly cutting down on time-to-market. Cradle also enables users to optimize multiple properties simultaneously, saving time and accelerating the learning process.

Key Features:

1. Protein Engineering Made Easy: Cradle simplifies protein engineering by providing a user-friendly interface that requires just a few clicks to design improved protein variants.

2. Predicted Performance Scores: Each generated sequence comes with a predicted performance score, allowing users to make informed decisions about which variant to pursue without relying solely on trial-and-error experimentation.

3. Multi-Property Optimization: Unlike traditional methods, Cradle is designed to handle multiple properties and optimization tasks in a single round. Users can optimize various characteristics such as activity, thermostability, solvent stability, solubility, substrate specificity, E-coli expression for proteins; epitope coverage for vaccines; enzyme efficiency for enzymes; and binding affinity for antibodies.

Use Cases:

1. Biotech Research Teams: Leading biotech teams use Cradle to accelerate new projects and revisit challenging ones by designing optimized protein variants more efficiently.

2. Pharmaceutical Industry: Cradle helps pharmaceutical companies streamline their drug discovery processes by rapidly generating high-performing protein sequences with desired properties.

3. Enzyme Engineering: Researchers working on enzyme engineering can leverage Cradle's multi-property optimization capabilities to enhance enzyme efficiency for various applications such as industrial processes or biofuel production.

Conclusion:

Cradle revolutionizes protein engineering by combining machine learning algorithms with user-friendly features that simplify the process of designing improved protein variants. Its ability to predict performance scores reduces uncertainty in the lab, saving time and resources. With Cradle, users can optimize multiple properties simultaneously, accelerating research and development in various industries such as biotech, pharmaceuticals, and enzyme engineering. By providing a secure platform that respects user privacy and ownership of intellectual property, Cradle empowers scientists to unlock the full potential of protein design.